Talk:Locus coeruleus

Neuroscience Mid‑importance

	This article is within the scope of WikiProject Neuroscience, a collaborative effort to improve the coverage of Neuroscience on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.NeuroscienceWikipedia:WikiProject NeuroscienceTemplate:WikiProject Neuroscienceneuroscience articles
Mid	This article has been rated as Mid-importance on the project's importance scale.

Anatomy: Neuroanatomy B‑class Mid‑importance

	This article is within the scope of WikiProject Anatomy, a collaborative effort to improve the coverage of Anatomy on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.AnatomyWikipedia:WikiProject AnatomyTemplate:WikiProject AnatomyAnatomy articles
B	This article has been given a rating which conflicts with the project-independent quality rating in the banner shell. Please resolve this conflict if possible.
Mid	This article has been rated as Mid-importance on the project's importance scale.
	This article has been classified as relating to neuroanatomy.

Autism Low‑importance

	This article is within the scope of WikiProject Autism, a collaborative effort to improve the coverage of all aspects of autism and autistic culture on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.AutismWikipedia:WikiProject AutismTemplate:WikiProject AutismAutism articles
Low	This article has been rated as Low-importance on the project's importance scale.

Needs expert opinion[edit]

This page, locus ceruleus, needs to be edited by an expert. I began to edit, but I am just a med student and do not have the time/expretise on the subject. Many of teh facts are fuzzy or questionable and there are no citations. __ I absolutely agree. This is a structure that plays a fundamental role not only in general arousal (i.e. alertness, drowsiness, etc.) but also plays a critical role in response selection during general task performance. The LC appears to play a large role in the extent to which we persist in optimizing human performance through the distribution of NE. It's a critical structure for behavior in general, and so some of that should be in here. I'm sure its role in PTSD is important, but that's perhaps a side-effect of what the structure actually DOES. Doesn't quite make sense that we have a little PTSD machine in our heads, eh? 76.199.1.210 05:05, 30 August 2007 (UTC)[reply]

Clearer Image?[edit]

As someone without any knowledge about this, I do not find the picture very enlightening. I would suggest that a picture with the LC clearly labeled would better fit in this article. The current picture seems quite old, and while that is not a bad thing on its own, maybe research has produced a more precise modern image. From the view of someone who is not a neurologist, its not even clear in what section of the brain this part is located. —Preceding unsigned comment added by 95.96.89.19 (talk) 07:11, 12 October 2010 (UTC)[reply]

At the very least, a calibration bar on each micrograph would be nice. —Preceding unsigned comment added by 58.166.216.136 (talk) 05:08, 6 February 2011 (UTC)[reply]

PTSD candidate circuit?[edit]

Can people provide references to what this is? Maybe start a separate article on this, or link appropriately? —Preceding unsigned comment added by 24.151.114.182 (talk) 23:34, 14 December 2007 (UTC)[reply]

LC Nomenclature[edit]

I suggest changing the main usage in this page to coeruleus (with the "oe"), rather than ceruleus. Although some people do prefer the term "ceruleus" (without the "o" -- a la the color "cerulean"), it is not the term used by the majority of scientists and neuroanatomists.

For example, a search for "locus coeruleus" using PubMed (the major repository for all meaningful biomedical research articles world-wide) returned 6646 articles, whereas "locus ceruleus" returned 1015 (many of which in fact used "coeruleus" in their text, but included "ceruleus" as a "Keyword" so that their article would not be missed in a search using the uncommon term; restricting the search to titles only resulted in 2032 "coeruleus" to 212 "ceruleus"). To make sure that "coeruleus" wasn't simply the preferred term many years ago (as suggested by the present version of this Wikipedia article), I restricted the results to the past five years (2004-2009), and the difference was just as large: 937 articles with "coeruleus" to just 152 with "ceruleus" (again, a six-to-one ratio). As an aside, "locus caeruleus" returned only 62 total hits (10 from the last 5 years).

My recommendation: avoid confusion (it's not like omitting the "o" makes this word any less ugly!) and stick with the established -- and more common -- nomenclature. Joel.geerling (talk) 21:46, 10 February 2009 (UTC)[reply]

I entirely agree with that, except oe should be written œ throughout the text. Nicolas Le Novere (talk) 19:05, 11 January 2010 (UTC)[reply]

The current edition of Terminologia Anatomica dictates "Nucleus caeruleus" (A14.1.05.436) in its list of Latin expressions but mentions "caerulean nucleus" in its list of English equivalents. In this classification the term "Locus caeruleus" (A14.1.05.706) corresponds to an area of the rhomboid fossa (floor of fourth ventricle). A current search for the term in Pubmed gives the following results. "Locus coeruleus" 6598 articles "Locus ceruleus" 1171 "Locus caeruleus" 73 "Locus coeruleus complex" 44 "Locus caeruleus complex" 6 "Loci coerulei" 7 "Loci cerulei" 2 "Caerulean nucleus" 0 "Nucleus caeruleus" 0

“Just because something is traditional is no reason to do it, of course.” ― Lemony Snicket, The Blank Book Gcastellanos (talk) 09:42, 29 May 2015 (UTC)[reply]

New subsection: Possible role in ASD[edit]

Would something on these lines be appropriate?

Research at Albert Einstein College of Medicine of Yeshiva University has suggested that the locus coeruleus - noradrenergic system (LC-NA) may be involved in autistic spectrum symptoms. They note that, "What is unique about the locus coeruleus is that it activates almost all higher-order brain centers that are involved in complex cognitive tasks." Yeshiva University news release Davy p (talk) 00:15, 21 April 2009 (UTC)[reply]

It has been said that...[edit]

I removed a logical impossibility: "...a single noradrenergic neuron can innervate the entire cerebral cortex via its branches" which had recently been tagged citation needed. The author may have been thinking of Olson & Fuxe 1971 which says that one single noradrenergic neuron of the rat LC can innervate both the cerebral and cerebellar cortices. (Cited in Léger & Hernandez-Nicaise 1980) Anthony (talk) 12:46, 10 February 2010 (UTC)[reply]

External links modified[edit]

Hello fellow Wikipedians,

I have just modified 2 external links on Locus coeruleus. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

Y An editor has reviewed this edit and fixed any errors that were found.

If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 03:34, 5 January 2018 (UTC)[reply]

Popular Culture[edit]

Big Bang Theory on anyone’s mind? Burlapbadger (talk) 03:00, 21 February 2020 (UTC)[reply]