Talk:Hsp90

cut & paste from Fink removed. TenOfAllTrades(talk) 15:09, 17 June 2006 (UTC)

Steroid Receptors

The article on heat shock proteins references this page and labels HSP90 as "Maintenance of steroid receptors and transcription factors." I'm really ignorant about this and was hoping to find this mentioned on this page. Can anybody help?doctorwolfie (talk) 11:34, 29 January 2008 (UTC)

I have added a new section to this article which briefly discusses the role of Hsp90 in normal cells and uses the glucocorticoid receptor (which is a type of steroid receptor) as an example. In short, Hsp90 is crucial in maintaining steroid receptors in a conformation that is capable of binding hormone and also assists in transporting the receptor from the cytoplasm into the nucleus. I hope this helps. Boghog2 (talk) 06:13, 30 June 2008 (UTC)

Ganetespib

On June 4, 2011, at the Annual Meeting of the American Society for Clinical Oncology (ASCO) a paper was presented on HSP-90 inhibitor ganetespib phase 2 non-small cell lung cancer trial results showing encouraging single agent clinical activity without eye or liver side effects. It is my understanding that ganetespib may be the only current HSP-90 inhibitor that is now showing broad spectrum efficacy with minimal side effects. If so, this remarkable development bears watching and perhaps will merit incorporation in the article. Frankatca (talk)frankatca —Preceding undated comment added 01:07, 5 June 2011 (UTC).

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HSP90 Inhibitor Trial

I'm starting an oral HSP90 inhibitor trial next week at MD Anderson made by Infinity Pharmaceuticals called IPI-493. I am JAK2 positive and being treated for myelofibrosis. The JAK2 inhibitors worked for one year for me then quit. If you're interested in progress, please feel free to drop me a line. --Saalanc (talk) 04:39, 12 June 2010 (UTC)

On a slightly related note. I added a link to a future HSP 90 inhibitor page that I hope with the help of a few students have up in a few days. Jasoninkid (talk) 16:30, 9 May 2011 (UTC)

Tumor repression?

The lead section claims that Hsp90 assists in tumor repression. Reading through the later sections, it appears to me that the opposite is true: it assists in the maintenance of tumors, by stabilizing mutant proteins, growth factor receptors, and signal transduction proteins. This explains why Hsp90 inhibitors are investigated as potential cancer medications--why would you want to inhibit a tumor repressor? AxelBoldt (talk) 23:43, 18 February 2012 (UTC)

OK, I removed "tumor repression" and instead mentioned its involvement in tumor growth and Hsp90 inhibitors in the intro. AxelBoldt (talk) 00:13, 25 February 2012 (UTC)

Role in evolution

I read Ed Yong's National Geographic article "How A Fish Unleashed Its Evolutionary Potential And Went Blind" and thought I should mention it here.

The suggestion is that Hsp90 plays a very important role in evolution by allowing genetic variation to accumulate without any phenotypic impact. A large amount of variation can then be trialled in offspring during long periods of stress, such as when the environment has permanently changed.

Yaris678 (talk) 20:24, 13 December 2013 (UTC)

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Hsp90 in Amyotrophic Lateral Sclerosis

Heat shock proteins frequently show up in the research literature on ALS and I wanted to just put in a mention but I could not figure out how to do that.

According to Miyazaki et. al. HSP90 (and HSP70) is higher in ALS than controls and remains high through the course of the disease. "The biological source of serum HSPs and the mechanisms mediating the increased expression of serum HSPs in patients with ALS remain unclear." dawot (talk) 13:02, 3 March 2019 (UTC)

References