Talk:Gene knockdown

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Untitled[edit]

I added references and removed the "unreferenced" tag (but forgot to log in first). JonMoulton (talk) 17:40, 25 April 2008 (UTC)[reply]

Knockdown Mutant[edit]

I would like to add a redirect from the term "Knockdown Mutant" to this page (once I learn how to make redirects that is).

If I don't hear from anyone who is against it I will assume its alright. Colincbn (talk) 07:28, 2 April 2009 (UTC)[reply]

What are the differences between knockouts and transient knockdowns?[edit]

What are the main differences between knockouts and transient knockdowns (apart from DNA change vs no DNA change)? Will the phenotype be the same? pgr94 (talk) 13:07, 27 December 2010 (UTC)[reply]

Did some digging: In these articles [1] PMID 18249134, there is a comparison of one gene in mice (knockdown vs knockout). Under the same conditions a difference in phenotype was observed. This article [2] reports "Array analysis revealed remarkable parallelism of transcriptomic changes in knockout and knockdown astrocytes, with similarly altered genes being located on all chromosomes and encoding proteins involved in a wide diversity of cell functions." pgr94 (talk) 14:19, 27 December 2010 (UTC)[reply]

Commercialization Section[edit]

This section is written like an ad. Should it be removed? 12.31.231.168 (talk) 17:34, 11 March 2015 (UTC)[reply]

Why discuss CRISPr and TALEN knockouts on a knockdown page?[edit]

The DNA changes induced by gene editing technologies lead to knockouts, not knockdowns. I don't understand why they are being duscussed on a page titled Gene Knockdown. Knockdowns are either genes modified at DNA level for reduced expression or technologies that halt gene expression at the RNA level (e.g. RNAi or antisense). JonMoulton (talk) 20:27, 22 October 2015 (UTC)[reply]