Talk:GBX2

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Summary[edit]

^[1]Gastrulation Brain Homeobox 2, or commonly known as GBX2, is a type of transcription factor that aids in the arranging of the midbrain and hindbrain during gastrulation. The hindbrain is broken up into seven or eight rhombomeres during gastrulation and GBX2 is responsible for rhombomeres one through three. GBX2 also takes part in the signaling and expression of other genes. It has been said that there is a threshold requirement for the amount of GBX2, so what occurs depends on the amount expressed. For example, specific amounts of GBX2 is needed for regulating the anterior and posterior patterning in the hindbrain. If the specific threshold is not met, then the patterning does not occur. This is the case with the other genes it helps to express like FGF8. With every gene comes some diseases associated with it. Colon Small Cell Carcinoma and Optiz-Gbbb Syndrome, which causes abnormalities throughout the midline of the body, are the diseases most closely associated with the GBX2 gene.

References

^ Waters, S. T. “A Threshold Requirement for Gbx2 Levels in Hindbrain Development.” Development, vol. 133, no. 10, 2006, pp. 1991–2000., doi:10.1242/dev.02364.

[1] Waters, S. T. “A Threshold Requirement for Gbx2 Levels in Hindbrain Development.” Development, vol. 133, no. 10, 2006, pp. 1991–2000., doi:10.1242/dev.02364.

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