Talk:Acetyl-Coenzyme A acetyltransferase

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Thiolase merge[edit]

Thiolase used to be a redirect to this article. Hodja Nasreddin removed the redirect in Oct. 2010 and started adding info to the Thiolase article. It seems like the two articles are talking about the same thing, so I don't think we need both articles. Cmcnicoll (talk) 22:26, 31 May 2011 (UTC)[reply]

Acetyl-CoA C-acetyltransferase merge[edit]

Acetyl-CoA C-acetyltransferase appears to be the same enzyme. I'm not sure which page should redirect to which. Cmcnicoll (talk) 22:37, 31 May 2011 (UTC)[reply]

Overlap[edit]

There appears to be some overlap in this article with the content of Acetyl-CoA C-acyltransferase. Should the material related to Acetyl-CoA C-acyltransferase be removed, or should the two articles be condensed into this one? Cmcnicoll (talk) 22:58, 31 May 2011 (UTC)[reply]

This article is misnamed (it does not correspond to any accepted IUBMB enzyme name). Therefore I think the material in this article should be moved to other articles. In addition, Acetyl-Coenzyme A acetyltransferase (this article) should be redirected to Acetyl-CoA C-acetyltransferase. Finally the following is a list of related protein and enzyme articles that I think need to be reorganized to minimize overlap:

Acetyl-Coenzyme A acetyltransferase – misnamed, material should be split up and the contents moved to the following three articles (Thiolase, EC 2.3.1.9 and EC 2.3.1.16):
Thiolase – a parent article based on the protein families Pfam PF00108 and Pfam PF02803 that have similar structures, this protein family includes at least three enzyme classes (EC 2.3.1.9, 2.3.1.16, and 2.3.1.176)
Acetyl-CoA C-acetyltransferase – EC 2.3.1.9, includes enzymes ACAT1, ACAT2
Acetyl-CoA C-acyltransferase – EC 2.3.1.16, includes enzymes ACAA1, ACAA2, HADHB
Propionyl-CoA C2-trimethyltridecanoyltransferase – EC 2.3.1.154
3-Oxoadipyl-CoA thiolase – EC 2.3.1.174
Propanoyl-CoA C-acyltransferase – EC 2.3.1.176, includes enzyme SCP2

Does this sound reasonable? Boghog (talk) 05:52, 1 June 2011 (UTC)[reply]

Also concerning the lead sentence in Gene Wiki articles such as ACAT1 and ACAA1, as discussed here and here, we have tried to make clear that these articles are not only about the human gene/protein, but also orthologs that exist in other species. The wording that was reached through consensus is perhaps a little awkward, but it is both accurate and concise:

<recommended UniProt name> is a protein that in humans is encoded by the <approved HUGO gene symbol> gene.

The "that" in the above sentence is non-limiting implying that the protein (and gene) exists in other species besides human. In addition, since much of the text in these articles focus on the properties of the protein (structure, function, interactions with other proteins), I think it is appropriate that emphasis in the lead is on the protein. Boghog (talk) 06:30, 1 June 2011 (UTC)[reply]

Thanks for the help! I definitely did not have the expertise for this, and I wasn't aware of the gene/protein page naming conventions. I appreciate the corrections. Cmcnicoll (talk) 07:01, 1 June 2011 (UTC)[reply]