NABP1

NABP1
Identifiers
Aliases	NABP1, OBFC2A, SOSS-B2, SSB2, nucleic acid binding protein 1
External IDs	OMIM: 612103 MGI: 1923258 HomoloGene: 57094 GeneCards: NABP1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	191,741,097 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	51,517,584 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; amniotic fluid; ; parietal pleura; ; spleen; ; stromal cell of endometrium; ; sperm; ; blood; ; visceral pleura; ; jejunal mucosa; ; oral cavity;
	Top expressed in
	thymus; ; seminiferous tubule; ; spermatid; ; brown adipose tissue; ; yolk sac; ; intercostal muscle; ; white adipose tissue; ; kidney; ; primitive streak; ; conjunctival fornix;
	More reference expression data
	n/a
Gene ontology
Molecular function	single-stranded DNA binding; DNA binding; protein binding; RNA binding;
Cellular component	nucleus; nucleoplasm; cytosol; SOSS complex;
Biological process	response to ionizing radiation; double-strand break repair via homologous recombination; DNA repair; cellular response to DNA damage stimulus; snRNA transcription by RNA polymerase II; mitotic cell cycle checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologs
	64859
	109019
	ENSG00000173559
	ENSMUSG00000026107
	Q96AH0
	Q8BGW5
	NM_001031716; NM_001254736; NM_022837
	NM_028696; NM_001310548; NM_001310549
	NP_001026886; NP_001241665
	NP_001297477; NP_001297478; NP_082972
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleic acid binding protein 1 is a protein that in humans is encoded by the NABP1 gene.^[5]

Function[edit]

Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173559 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026107 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Nucleic acid binding protein 1".
^ Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK (May 2008). "Single-stranded DNA-binding protein hSSB1 is critical for genomic stability". Nature. 453 (7195): 677–81. Bibcode:2008Natur.453..677R. doi:10.1038/nature06883. PMID 18449195. S2CID 4322436.

Further reading[edit]

Li Y, Bolderson E, Kumar R, Muniandy PA, Xue Y, Richard DJ, Seidman M, Pandita TK, Khanna KK, Wang W (August 2009). "HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response". The Journal of Biological Chemistry. 284 (35): 23525–31. doi:10.1074/jbc.C109.039586. PMC 2749126. PMID 19605351.
Huang J, Gong Z, Ghosal G, Chen J (August 2009). "SOSS complexes participate in the maintenance of genomic stability". Molecular Cell. 35 (3): 384–93. doi:10.1016/j.molcel.2009.06.011. PMC 2756616. PMID 19683501.
Malovannaya A, Li Y, Bulynko Y, Jung SY, Wang Y, Lanz RB, O'Malley BW, Qin J (February 2010). "Streamlined analysis schema for high-throughput identification of endogenous protein complexes". Proceedings of the National Academy of Sciences of the United States of America. 107 (6): 2431–6. Bibcode:2010PNAS..107.2431M. doi:10.1073/pnas.0912599106. PMC 2823922. PMID 20133760.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173559 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026107 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Nucleic acid binding protein 1".

[6] Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK (May 2008). "Single-stranded DNA-binding protein hSSB1 is critical for genomic stability". Nature. 453 (7195): 677–81. Bibcode:2008Natur.453..677R. doi:10.1038/nature06883. PMID 18449195. S2CID 4322436.

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