MSRB2

MSRB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L1U
Identifiers
Aliases	MSRB2, CBS-1, CBS1, MSRB, PILB, CGI-131, methionine sulfoxide reductase B2
External IDs	OMIM: 613782 MGI: 1923717 HomoloGene: 56555 GeneCards: MSRB2
Gene location (Human)
Chr.	Chromosome 10 (human)
End	23,122,013 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	19,399,787 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; vena cava; ; left ventricle; ; biceps brachii; ; triceps brachii muscle; ; thoracic diaphragm; ; saphenous vein; ; body of tongue; ; nucleus accumbens; ; optic nerve;
	Top expressed in
	interventricular septum; ; myocardium of ventricle; ; cardiac muscles; ; right ventricle; ; proximal tubule; ; cervix; ; skeletal muscle tissue; ; brown adipose tissue; ; kidney; ; facial motor nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; oxidoreductase activity; actin binding; zinc ion binding; metal ion binding; peptide-methionine (R)-S-oxide reductase activity; L-methionine-(R)-S-oxide reductase activity;
Cellular component	cytosol; mitochondrion;
Biological process	actin filament polymerization; response to oxidative stress; protein repair; regulation of transcription, DNA-templated; cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologs
	22921
	76467
	ENSG00000148450
	ENSMUSG00000023094
	Q9Y3D2
	Q78J03
	NM_012228
	NM_029619
	NP_036360
	NP_083895
	Wikidata
View/Edit Human	View/Edit Mouse

Methionine-R-sulfoxide reductase B2, mitochondrial is an enzyme that in humans is encoded by the MSRB2 gene.^[5]^[6]^[7] The MRSB2 enzyme catalyzes the reduction of methionine sulfoxide to methionine.

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148450 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023094 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Escribano J, Ortego J, Coca-Prados M (Jan 1997). "Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins". J Biochem. 118 (5): 921–31. doi:10.1093/jb/118.5.921. PMID 8749308.
^ Huang W, Escribano J, Sarfarazi M, Coca-Prados M (Aug 1999). "Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases". Gene. 233 (1–2): 233–40. doi:10.1016/S0378-1119(99)00131-6. PMID 10375640.
^ "Entrez Gene: MSRB2 methionine sulfoxide reductase B2".

Further reading[edit]

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Jung S, Hansel A, Kasperczyk H, et al. (2002). "Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1". FEBS Lett. 527 (1–3): 91–4. doi:10.1016/S0014-5793(02)03171-X. PMID 12220640. S2CID 2170229.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim HY, Gladyshev VN (2004). "Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases". Mol. Biol. Cell. 15 (3): 1055–64. doi:10.1091/mbc.E03-08-0629. PMC 363075. PMID 14699060.
Picot CR, Perichon M, Cintrat JC, et al. (2004). "The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts". FEBS Lett. 558 (1–3): 74–8. doi:10.1016/S0014-5793(03)01530-8. PMID 14759519. S2CID 32573388.
Hansel A, Jung S, Hoshi T, Heinemann SH (2004). "A second human methionine sulfoxide reductase (hMSRB2) reducing methionine-R-sulfoxide displays a tissue expression pattern distinct from hMSRB1". Redox Rep. 8 (6): 384–8. doi:10.1179/135100003225003429. PMID 14980072.
Schallreuter KU, Rübsam K, Chavan B, et al. (2006). "Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus". Biochem. Biophys. Res. Commun. 342 (1): 145–52. doi:10.1016/j.bbrc.2006.01.124. PMID 16480945.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148450 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023094 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8749308-5] Escribano J, Ortego J, Coca-Prados M (Jan 1997). "Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins". J Biochem. 118 (5): 921–31. doi:10.1093/jb/118.5.921. PMID 8749308.

[pmid10375640-6] Huang W, Escribano J, Sarfarazi M, Coca-Prados M (Aug 1999). "Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases". Gene. 233 (1–2): 233–40. doi:10.1016/S0378-1119(99)00131-6. PMID 10375640.

[entrez-7] "Entrez Gene: MSRB2 methionine sulfoxide reductase B2".

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See also[edit]

References[edit]

Further reading[edit]