METTL14

METTL14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IL1, 5K7W, 5IL2, 5IL0, 5K7M, 5K7U
Identifiers
Aliases	METTL14, methyltransferase like 14, hmethyltransferase 14, N6-adenosine-methyltransferase subunit
External IDs	OMIM: 616504 MGI: 2442926 HomoloGene: 10865 GeneCards: METTL14
Gene location (Human) Chr. Chromosome 4 (human) Band 4q26 Start 118,685,392 bp End 118,715,433 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 G1 Start 123,161,946 bp End 123,179,757 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon secondary oocyte islet of Langerhans caput epididymis corpus epididymis thymus pancreatic epithelial cell smooth muscle tissue bone marrow ganglionic eminence Top expressed in hand ascending aorta aortic valve otolith organ utricle primitive streak supraoptic nucleus ureter soleus muscle abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function RNA binding mRNA binding S-adenosyl-L-methionine binding protein binding mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Cellular component RNA N6-methyladenosine methyltransferase complex nucleus nucleoplasm Biological process stem cell population maintenance mRNA splicing, via spliceosome mRNA destabilization mRNA methylation RNA methylation mRNA catabolic process spermatogenesis forebrain radial glial cell differentiation gliogenesis cell differentiation RNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57721 210529 Ensembl ENSG00000145388 ENSMUSG00000028114 UniProt Q9HCE5 Q3UIK4 RefSeq (mRNA) NM_020961 NM_201638 RefSeq (protein) NP_066012 NP_964000 Location (UCSC) Chr 4: 118.69 – 118.72 Mb Chr 3: 123.16 – 123.18 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Methyltransferase like 14 is a protein that in humans is encoded by the METTL14 gene.

Further reading

• Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP (June 2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Hum. Mol. Genet. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
• Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C (February 2014). "A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation". Nat. Chem. Biol. 10 (2): 93–5. doi:10.1038/nchembio.1432. PMC 3911877. PMID 24316715.
• Wang X, Feng J, Xue Y, Guan Z, Zhang D, Liu Z, Gong Z, Wang Q, Huang J, Tang C, Zou T, Yin P (June 2016). "Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex". Nature. 534 (7608): 575–8. Bibcode:2016Natur.534..575W. doi:10.1038/nature18298. PMID 27281194. S2CID 4448430.
• Śledź P, Jinek M (September 2016). "Structural insights into the molecular mechanism of the m(6)A writer complex". eLife. 5. doi:10.7554/eLife.18434. PMC 5023411. PMID 27627798.