MEMO1

MEMO1
Identifiers
Aliases	MEMO1, C2orf4, MEMO, NS5ATP7, CGI-27, mediator of cell motility 1
External IDs	OMIM: 611786 MGI: 1924140 HomoloGene: 6272 GeneCards: MEMO1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	32,011,230 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	74,602,516 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; monocyte; ; corpus callosum; ; lymph node; ; left ventricle; ; ganglionic eminence; ; islet of Langerhans; ; left adrenal gland; ; appendix; ; blood;
	Top expressed in
	spermatocyte; ; blood; ; lens; ; spermatid; ; hair follicle; ; seminiferous tubule; ; lip; ; esophagus; ; ascending aorta; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	nucleus; cytosol;
Biological process	regulation of microtubule-based process; regulation of cell motility;
	Sources:Amigo / QuickGO
Orthologs
	51072
	76890
	ENSG00000162959
	ENSMUSG00000058704
	Q9Y316
	Q91VH6
	NM_001137602; NM_015955; NM_001301833; NM_001301852
	NM_133771
NP_001131074; NP_001288762; NP_001288781; NP_057039; NP_001358841;
	NP_001358842; NP_001358843; NP_001358844; NP_001358845; NP_001358846; NP_001358847; NP_001358849; NP_001358850
	NP_598532
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of cell motility 1 is a protein that in humans is encoded by the MEMO1 gene.^[5]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162959 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058704 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Mediator of cell motility 1".

Further reading[edit]

Meira M, Masson R, Stagljar I, Lienhard S, Maurer F, Boulay A, Hynes NE (March 2009). "Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration". Journal of Cell Science. 122 (Pt 6): 787–97. doi:10.1242/jcs.032094. PMID 19223396.
Marone R, Hess D, Dankort D, Muller WJ, Hynes NE, Badache A (June 2004). "Memo mediates ErbB2-driven cell motility". Nature Cell Biology. 6 (6): 515–22. doi:10.1038/ncb1134. PMID 15156151. S2CID 23073115.
Reymond A, Friedli M, Henrichsen CN, Chapot F, Deutsch S, Ucla C, Rossier C, Lyle R, Guipponi M, Antonarakis SE (November 2001). "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map". Genomics. 78 (1–2): 46–54. doi:10.1006/geno.2001.6640. PMID 11707072.
Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ (February 2008). "Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site". The Journal of Biological Chemistry. 283 (5): 2734–40. doi:10.1074/jbc.M703523200. PMID 18045866.
Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem P, Lehrach H, Yaspo ML, Janitz M (June 2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
Zaoui K, Honoré S, Isnardon D, Braguer D, Badache A (November 2008). "Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells". The Journal of Cell Biology. 183 (3): 401–8. doi:10.1083/jcb.200805107. PMC 2575782. PMID 18955552.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162959 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058704 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Mediator of cell motility 1".

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