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Protein-coding gene in the species Homo sapiens
Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene .[5] [6] Mediator complex . The family contains the Saccharomyces cerevisiae SOH1 homologues . SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant [7] transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.[8]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000108590 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020801 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics" . Genome Res . 10 (5): 703–713. doi :10.1101/gr.10.5.703 . PMC 310876 PMID 10810093 . ^ "Entrez Gene: MED31 mediator of RNA polymerase II transcription, subunit 31 homolog (S. cerevisiae)" .^ Fan HY, Klein HL (August 1994). "Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae" . Genetics . 137 (4): 945–56. doi :10.1093/genetics/137.4.945 . PMC 1206071 PMID 7982575 . ^ Fan HY, Cheng KK, Klein HL (March 1996). "Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae" . Genetics . 142 (3): 749–59. doi :10.1093/genetics/142.3.749 . PMC 1207016 PMID 8849885 .
Further reading [ edit ]
Gu W, Malik S, Ito M, et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation" . Mol. Cell . 3 (1): 97–108. doi :10.1016/S1097-2765(00)80178-1 PMID 10024883 . Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs" . Genome Res . 11 (10): 1758–1765. doi :10.1101/gr.180101 . PMC 311163 PMID 11591653 . Brower CS, Sato S, Tomomori-Sato C, et al. (2002). "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase" . Proc. Natl. Acad. Sci. U.S.A . 99 (16): 10353–10358. Bibcode :2002PNAS...9910353B . doi :10.1073/pnas.162424199 PMC 124918 PMID 12149480 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3" . J. Biol. Chem . 278 (17): 15123–15127. doi :10.1074/jbc.C300054200 PMID 12584197 . Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex" . J. Biol. Chem . 278 (50): 49671–49674. doi :10.1074/jbc.C300444200 PMID 14576168 . Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2" . J. Biol. Chem . 279 (7): 5846–5851. doi :10.1074/jbc.M312523200 PMID 14638676 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–45. doi :10.1038/ng1285 PMID 14702039 . Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology" . Mol. Cell . 14 (5): 685–691. doi :10.1016/j.molcel.2004.05.006 PMID 15175163 . Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease" . Mol. Cell . 15 (6): 853–865. doi :10.1016/j.molcel.2004.09.016 PMID 15383276 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome" . Cell . 122 (6): 957–968. doi :10.1016/j.cell.2005.08.029 hdl :11858/00-001M-0000-0010-8592-0 PMID 16169070 .
