GTF3C4

GTF3C4
Identifiers
Aliases	GTF3C4, KAT12, TFIII90, TFIIIC290, TFIIIC90, TFIIICDELTA, TF3C-delta, general transcription factor IIIC subunit 4
External IDs	OMIM: 604892 MGI: 2138937 HomoloGene: 8147 GeneCards: GTF3C4
Gene location (Human)
Chr.	Chromosome 9 (human)
End	132,694,953 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	28,840,360 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; ganglionic eminence; ; hair follicle; ; stromal cell of endometrium; ; middle temporal gyrus; ; Brodmann area 23; ; tibia; ; parietal pleura; ; sperm; ; smooth muscle tissue;
	Top expressed in
	ureter; ; medullary collecting duct; ; saccule; ; otic placode; ; vas deferens; ; renal corpuscle; ; fossa; ; condyle; ; primitive streak; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone acetyltransferase activity; transferase activity; DNA binding; enzyme activator activity; acyltransferase activity; protein binding;
Cellular component	transcription factor TFIIIC complex; nucleoplasm; nucleus; mitochondrion;
Biological process	tRNA transcription by RNA polymerase III; 5S class rRNA transcription by RNA polymerase III; transcription initiation from RNA polymerase III promoter; transcription, DNA-templated; positive regulation of catalytic activity; transcription by RNA polymerase III; histone acetylation;
	Sources:Amigo / QuickGO
Orthologs
	9329
	269252
	ENSG00000125484
	ENSMUSG00000035666
	Q9UKN8
	Q8BMQ2
	NM_012204
	NM_001166033; NM_172977
	NP_036336
	NP_001159505; NP_766565
	Wikidata
View/Edit Human	View/Edit Mouse

General transcription factor 3C polypeptide 4 is a protein that in humans is encoded by the GTF3C4 gene.^[5]^[6]

Interactions[edit]

GTF3C4 has been shown to interact with GTF3C2,^[5] GTF3C1,^[5] POLR3C^[5]^[7] and GTF3C5.^[5]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125484 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035666 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c ^d ^e Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
^ "Entrez Gene: GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa".
^ Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.

Further reading[edit]

Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC". J. Biol. Chem. 282 (23): 17179–89. doi:10.1074/jbc.M611542200. PMID 17409385.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Hsieh YJ, Wang Z, Kovelman R, Roeder RG (1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125484 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035666 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10523658-5] Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.

[entrez-6] "Entrez Gene: GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa".

[pmid10373544-7] Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.

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