Deoxyribonuclease ii, lysosomal

DNASE2
Identifiers
Aliases	DNASE2, DNASE2A, DNL, DNL2, deoxyribonuclease II, lysosomal, deoxyribonuclease 2, lysosomal, AIPCS
External IDs	OMIM: 126350 MGI: 1329019 HomoloGene: 68179 GeneCards: DNASE2
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.13 Start 12,875,209 bp End 12,881,466 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell stromal cell of endometrium external globus pallidus parotid gland cardia monocyte vena cava pylorus subthalamic nucleus lymph node n/a More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding nuclease activity endonuclease activity endodeoxyribonuclease activity hydrolase activity deoxyribonuclease II activity Cellular component lysosome extracellular exosome intracellular anatomical structure Biological process erythrocyte differentiation multicellular organism development DNA metabolic process DNA catabolic process DNA catabolic process, endonucleolytic apoptotic process apoptotic DNA fragmentation regulation of immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1777 13423 Ensembl ENSG00000105612 ENSMUSG00000003812 UniProt O00115 P56542 RefSeq (mRNA) NM_001375 NM_010062 NM_001368295 NM_001368296 RefSeq (protein) NP_001366 NP_001366.1 NP_034192 NP_001355224 NP_001355225 Location (UCSC) Chr 19: 12.88 – 12.88 Mb n/a PubMed search
Wikidata
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Deoxyribonuclease II, lysosomal is a protein that in humans is encoded by the DNASE2 gene.

Function

This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis.

Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.

Further reading

• Chou SF, Chen HL, Lu SC (2002). "Up-regulation of human deoxyribonuclease II gene expression during myelomonocytic differentiation of HL-60 and THP-1 cells". Biochem. Biophys. Res. Commun. 296 (1): 48–53. doi:10.1016/s0006-291x(02)00835-5. PMID 12147225.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.