DHX34

DHX34
Identifiers
Aliases	DHX34, DDX34, HRH1, DEAH-box helicase 34, DExH-box helicase 34
External IDs	OMIM: 615475 MGI: 1918973 HomoloGene: 69171 GeneCards: DHX34
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.32 Start 47,349,315 bp End 47,382,704 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A2 Start 15,931,072 bp End 15,955,962 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood spleen right uterine tube right lobe of liver anterior pituitary canal of the cervix right lobe of thyroid gland left lobe of thyroid gland left uterine tube upper lobe of left lung Top expressed in spermatocyte seminiferous tubule yolk sac esophagus submandibular gland islet of Langerhans spermatid stomach internal carotid artery external carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding hydrolase activity ATP binding helicase activity RNA binding 3'-5' RNA helicase activity Cellular component membrane cytoplasm Biological process nuclear-transcribed mRNA catabolic process RNA processing negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9704 71723 Ensembl ENSG00000134815 ENSMUSG00000006019 UniProt Q14147 Q9DBV3 RefSeq (mRNA) NM_014681 NM_194428 NM_001285931 NM_001285932 NM_027883 RefSeq (protein) NP_055496 NP_001272860 NP_001272861 NP_082159 Location (UCSC) Chr 19: 47.35 – 47.38 Mb Chr 7: 15.93 – 15.96 Mb PubMed search
Wikidata
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DExH-box helicase 34 is a protein that in humans is encoded by the DHX34 gene.

Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008].

Further reading

• Longman D, Hug N, Keith M, Anastasaki C, Patton EE, Grimes G, Cáceres JF (September 2013). "DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans". Nucleic Acids Res. 41 (17): 8319–31. doi:10.1093/nar/gkt585. PMC 3783168. PMID 23828042.
• Hug N, Cáceres JF (September 2014). "The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex". Cell Rep. 8 (6): 1845–1856. doi:10.1016/j.celrep.2014.08.020. PMC 4534575. PMID 25220460.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.