DDO (gene)

DDO
Identifiers
Aliases	DDO, Ddo, 5330420D20Rik, 5730402C02Rik, AI467244, DASOX, DDO-1, DDO-2, D-aspartate oxidase
External IDs	OMIM: 124450 MGI: 1925528 HomoloGene: 101531 GeneCards: DDO
Gene location (Human) Chr. Chromosome 6 (human) Band 6q21 Start 110,391,771 bp End 110,415,562 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B1 Start 40,506,007 bp End 40,557,843 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ventricle right ventricle myocardium right adrenal gland left adrenal gland kidney tubule right lobe of liver putamen caudate nucleus endothelial cell Top expressed in digastric muscle sternocleidomastoid muscle temporal muscle triceps brachii muscle soleus muscle parotid gland myocardium of ventricle interventricular septum intercostal muscle substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity FAD binding signaling receptor binding protein binding D-amino-acid oxidase activity D-aspartate oxidase activity Cellular component peroxisome peroxisomal matrix cytosol cytoplasm Biological process insemination grooming behavior aspartate metabolic process D-amino acid metabolic process hormone metabolic process aspartate catabolic process D-amino acid catabolic process cellular nitrogen compound metabolic process protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8528 70503 Ensembl ENSG00000203797 ENSMUSG00000063428 UniProt Q99489 Q922Z0 RefSeq (mRNA) NM_003649 NM_004032 NM_027442 NM_001316716 NM_001316717 NM_001316718 NM_001316719 RefSeq (protein) NP_004023 NP_001355099 NP_001355100 NP_001355101 NP_001355102 NP_001355103 NP_001355104 NP_001359037 NP_001303645 NP_001303646 NP_001303647 NP_001303648 NP_081718 Location (UCSC) Chr 6: 110.39 – 110.42 Mb Chr 10: 40.51 – 40.56 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

D-aspartate oxidase is an enzyme that is encoded by the DDO gene.

The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two (or four, according to Q99489) transcript variants encoding different isoforms have been found for this gene.

Further reading

• Barker RF, Hopkinson DA (1977). "The genetic and biochemical properties of the D-amino acid oxidases in human tissues". Ann. Hum. Genet. 41 (1): 27–42. doi:10.1111/j.1469-1809.1977.tb01959.x. PMID 21608. S2CID 40488767.
• Van Veldhoven PP, Brees C, Mannaerts GP (1991). "D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man". Biochim. Biophys. Acta. 1073 (1): 203–8. doi:10.1016/0304-4165(91)90203-S. PMID 1991137.
• Nagasaki H (1994). "Gender-related differences of mouse liver D-aspartate oxidase in the activity and response to administration of D-aspartate and peroxisome proliferators". Int. J. Biochem. 26 (3): 415–23. doi:10.1016/0020-711X(94)90062-0. PMID 8187937.
• Simonic T, Duga S, Negri A, et al. (1997). "cDNA cloning and expression of the flavoprotein D-aspartate oxidase from bovine kidney cortex". Biochem. J. 322 (3): 729–35. doi:10.1042/bj3220729. PMC 1218248. PMID 9148742.
• Amery L, Brees C, Baes M, et al. (1999). "C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal". Biochem. J. 336 (2): 367–71. doi:10.1042/bj3360367. PMC 1219880. PMID 9820813.
• Zaar K, Köst HP, Schad A, et al. (2002). "Cellular and subcellular distribution of D-aspartate oxidase in human and rat brain". J. Comp. Neurol. 450 (3): 272–82. doi:10.1002/cne.10320. PMID 12209855. S2CID 24459809.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.