CLSTN1

CLSTN1
Identifiers
Aliases	CLSTN1, ALC-ALPHA, CDHR12, CSTN1, PIK3CD, XB31alpha, alcalpha1, alcalpha2, CST-1, calsyntenin 1
External IDs	OMIM: 611321 MGI: 1929895 HomoloGene: 8814 GeneCards: CLSTN1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	9,823,984 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	149,733,356 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; postcentral gyrus; ; Brodmann area 10; ; middle temporal gyrus; ; orbitofrontal cortex; ; superior frontal gyrus; ; Brodmann area 46; ; cerebellar vermis; ; Brodmann area 9; ; entorhinal cortex;
	Top expressed in
	primary motor cortex; ; cingulate gyrus; ; prefrontal cortex; ; habenula; ; superior frontal gyrus; ; medial dorsal nucleus; ; piriform cortex; ; medial geniculate nucleus; ; subiculum; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	X11-like protein binding; calcium ion binding; amyloid-beta binding; protein binding; kinesin binding;
Cellular component	integral component of membrane; postsynaptic membrane; Golgi apparatus; cell projection; endoplasmic reticulum membrane; membrane; Golgi membrane; plasma membrane; synapse; extracellular region; cell surface; cell junction; endoplasmic reticulum; nucleus; postsynaptic density; postsynaptic endosome; glutamatergic synapse; GABA-ergic synapse; integral component of postsynaptic density membrane; integral component of spine apparatus membrane;
Biological process	cell adhesion; positive regulation of synaptic transmission; regulation of cell growth; homophilic cell adhesion via plasma membrane adhesion molecules; positive regulation of synapse assembly; regulation of synapse maturation; neurotransmitter receptor transport to postsynaptic membrane; vesicle-mediated transport in synapse;
	Sources:Amigo / QuickGO
Orthologs
	22883
	65945
	ENSG00000171603
	ENSMUSG00000039953
	O94985
	Q9EPL2
	NM_014944; NM_001009566; NM_001302883
	NM_001290989; NM_023051
	NP_001009566; NP_001289812; NP_055759
	NP_001277918; NP_075538
	Wikidata
View/Edit Human	View/Edit Mouse

Calsyntenin-1 is a protein that in humans is encoded by the CLSTN1 gene.^[5]^[6]

Clinical relevance[edit]

Mutations in this gene have been shown associated to pathogenic mechanisms of Alzheimer's disease.^[7]

Interactions[edit]

CLSTN1 has been shown to interact with APBA2^[8]^[9] and Amyloid precursor protein.^[8]^[9]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171603 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039953 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
^ "Entrez Gene: CLSTN1 calsyntenin 1".
^ Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC (Jul 2012). "Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production". Human Molecular Genetics. 21 (13): 2845–54. doi:10.1093/hmg/dds109. PMC 3373235. PMID 22434822.
^ ^a ^b Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003). "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological Chemistry. 278 (49): 49448–58. doi:10.1074/jbc.M306024200. PMID 12972431.
^ ^a ^b Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004). "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". The Journal of Biological Chemistry. 279 (23): 24343–54. doi:10.1074/jbc.M401925200. PMID 15037614.

External links[edit]

Human CLSTN1 genome location and CLSTN1 gene details page in the UCSC Genome Browser.
Human PIK3CD genome location and PIK3CD gene details page in the UCSC Genome Browser.

Further reading[edit]

Konecna A, Frischknecht R, Kinter J, Ludwig A, Steuble M, Meskenaite V, Indermühle M, Engel M, Cen C, Mateos JM, Streit P, Sonderegger P (Aug 2006). "Calsyntenin-1 docks vesicular cargo to kinesin-1" (PDF). Molecular Biology of the Cell. 17 (8): 3651–63. doi:10.1091/mbc.E06-02-0112. PMC 1525238. PMID 16760430.^{[permanent dead link]}
Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA (Jun 2004). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nature Biotechnology. 22 (6): 724–31. doi:10.1038/nbt969. PMID 15146195. S2CID 36630738.
Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004). "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". The Journal of Biological Chemistry. 279 (23): 24343–54. doi:10.1074/jbc.M401925200. PMID 15037614.
Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003). "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological Chemistry. 278 (49): 49448–58. doi:10.1074/jbc.M306024200. PMID 12972431.
Nakayama M, Kikuno R, Ohara O (Nov 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Vogt L, Schrimpf SP, Meskenaite V, Frischknecht R, Kinter J, Leone DP, Ziegler U, Sonderegger P (Jan 2001). "Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain". Molecular and Cellular Neurosciences. 17 (1): 151–66. doi:10.1006/mcne.2000.0937. PMID 11161476. S2CID 30856590.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171603 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039953 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10048485-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

[entrez-6] "Entrez Gene: CLSTN1 calsyntenin 1".

[doi.10.1093/hmg/dds109-7] Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC (Jul 2012). "Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production". Human Molecular Genetics. 21 (13): 2845–54. doi:10.1093/hmg/dds109. PMC 3373235. PMID 22434822.

[pmid12972431-8] Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003). "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological Chemistry. 278 (49): 49448–58. doi:10.1074/jbc.M306024200. PMID 12972431.

[pmid15037614-9] Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004). "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". The Journal of Biological Chemistry. 279 (23): 24343–54. doi:10.1074/jbc.M401925200. PMID 15037614.

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