CDC26

CDC26
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HYM, 4UI9, 5A31, 5G05, 5G04,%%s4UI9, 5A31
Identifiers
Aliases	CDC26, ANAPC12, APC12, C9orf17, cell division cycle 26
External IDs	OMIM: 614533 MGI: 1913690 HomoloGene: 16410 GeneCards: CDC26
Gene location (Human)
Chr.	Chromosome 9 (human)
End	113,275,572 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	62,326,879 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; monocyte; ; islet of Langerhans; ; lymph node; ; left ventricle; ; rectum; ; right lung; ; endometrium; ; left coronary artery; ; kidney;
	Top expressed in
	medial ganglionic eminence; ; yolk sac; ; abdominal wall; ; endocardial cushion; ; maxillary prominence; ; dermis; ; thymus; ; otic placode; ; intercostal muscle; ; seminal vesicula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; anaphase-promoting complex; nucleus; nucleoplasm;
Biological process	regulation of mitotic metaphase/anaphase transition; cell cycle; anaphase-promoting complex-dependent catabolic process; protein ubiquitination; protein K11-linked ubiquitination; cell division; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process; regulation of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	246184
	66440
	ENSG00000176386
	ENSMUSG00000066149
	Q8NHZ8
	Q99JP4
	NM_139286
	NM_139291; NM_001368241
	NP_644815; NP_644815.1
	NP_647452; NP_001355170
	Wikidata
View/Edit Human	View/Edit Mouse

Cell division cycle 26 is a protein that in humans is encoded by the CDC26 gene.^[5]

Function[edit]

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008].

External links[edit]

PDBe-KB provides an overview of all the structure information available in the PDB for Human Anaphase-promoting complex subunit CDC26

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176386 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066149 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Cell division cycle 26". Retrieved 2018-10-16.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176386 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066149 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Cell division cycle 26". Retrieved 2018-10-16.

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