CCDC88A

CCDC88A
Identifiers
Aliases	CCDC88A, APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212, coiled-coil domain containing 88A, PEHO, PEHOL
External IDs	OMIM: 609736 MGI: 1925177 HomoloGene: 41180 GeneCards: CCDC88A
Gene location (Human)
Chr.	Chromosome 2 (human)
End	55,419,895 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	29,460,808 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; corpus callosum; ; ganglionic eminence; ; Achilles tendon; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; external globus pallidus; ; superior vestibular nucleus; ; monocyte; ; amygdala;
	Top expressed in
	barrel cortex; ; lateral geniculate nucleus; ; mammillary body; ; ventromedial nucleus; ; spermatid; ; ventral tegmental area; ; lateral hypothalamus; ; pontine nuclei; ; ganglionic eminence; ; substantia nigra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; phosphatidylinositol binding; actin binding; microtubule binding; protein kinase B binding; dynein light intermediate chain binding; G-protein gamma-subunit binding;
Cellular component	cytoplasm; Golgi apparatus; cell projection; endoplasmic reticulum; lamellipodium; membrane; cytoplasmic vesicle; cytosol; plasma membrane; cell leading edge; centrosome; centriole; cytoskeleton; ciliary basal body; COPI-coated Golgi to ER transport vesicle;
Biological process	regulation of actin cytoskeleton organization; nervous system development; DNA replication; membrane organization; cell migration; lamellipodium assembly; activation of protein kinase B activity; regulation of DNA replication; TOR signaling; regulation of protein phosphorylation; regulation of cell population proliferation; regulation of neuron projection development; cell projection organization; cytoskeleton-dependent intracellular transport; cytoplasmic microtubule organization; positive regulation of cilium assembly; positive regulation of protein localization to cilium;
	Sources:Amigo / QuickGO
Orthologs
	55704
	108686
	ENSG00000115355
	ENSMUSG00000032740
	Q3V6T2
	Q5SNZ0
	NM_001135597; NM_001254943; NM_018084; NM_001365480
	NM_176841; NM_001363368; NM_001363369
	NP_001129069; NP_001241872; NP_060554; NP_001352409
	NP_789811; NP_001350297; NP_001350298
	Wikidata
View/Edit Human	View/Edit Mouse

Girdin is a protein that in humans is encoded by the CCDC88A gene.^[5]^[6]^[7] Although its cellular function are not fully elucidated, it has been associated with glioma.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115355 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032740 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG (Jun 2005). "Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles". J Biol Chem. 280 (23): 22012–20. doi:10.1074/jbc.M501833200. PMID 15749703.
^ Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T (May 2005). "A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis". J Biol Chem. 280 (18): 18525–35. doi:10.1074/jbc.M500586200. PMID 15753085.
^ "Entrez Gene: KIAA1212 KIAA1212".
^ Gu, F.; Wang, L.; He, J.; Liu, X.; Zhang, H.; Li, W.; Fu, L.; Ma, Y. (2014). "Girdin, an actin-binding protein, is critical for migration, adhesion, and invasion of human glioblastoma cells". Journal of Neurochemistry. 131 (4): 457–469. doi:10.1111/jnc.12831. PMID 25060559. S2CID 206090300.

External links[edit]

DISC1 Players Gird For Adult Neurodevelopment - Schizophrenia Research Forum, 8 oct 2009
Human CCDC88A genome location and CCDC88A gene details page in the UCSC Genome Browser.

Further reading[edit]

Kitamura T, Asai N, Enomoto A, et al. (2008). "Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin". Nat. Cell Biol. 10 (3): 329–37. doi:10.1038/ncb1695. PMID 18264090. S2CID 23157573.
Enomoto A, Murakami H, Asai N, et al. (2005). "Akt/PKB regulates actin organization and cell motility via Girdin/APE". Dev. Cell. 9 (3): 389–402. doi:10.1016/j.devcel.2005.08.001. PMID 16139227.
Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442. S2CID 25389776.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115355 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032740 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15749703-5] Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG (Jun 2005). "Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles". J Biol Chem. 280 (23): 22012–20. doi:10.1074/jbc.M501833200. PMID 15749703.

[pmid15753085-6] Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T (May 2005). "A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis". J Biol Chem. 280 (18): 18525–35. doi:10.1074/jbc.M500586200. PMID 15753085.

[entrez-7] "Entrez Gene: KIAA1212 KIAA1212".

[8] Gu, F.; Wang, L.; He, J.; Liu, X.; Zhang, H.; Li, W.; Fu, L.; Ma, Y. (2014). "Girdin, an actin-binding protein, is critical for migration, adhesion, and invasion of human glioblastoma cells". Journal of Neurochemistry. 131 (4): 457–469. doi:10.1111/jnc.12831. PMID 25060559. S2CID 206090300.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]