C7orf31

C7orf31
Identifiers
Aliases	C7orf31, chromosome 7 open reading frame 31
External IDs	OMIM: 616071 MGI: 1918071 HomoloGene: 69433 GeneCards: C7orf31
Gene location (Human)
Chr.	Chromosome 7 (human)
End	25,180,356 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	50,573,612 bp
RNA expression pattern
	Top expressed in
	sperm; ; retinal pigment epithelium; ; monocyte; ; left adrenal gland; ; bone marrow cells; ; palpebral conjunctiva; ; rectum; ; popliteal artery; ; tibia; ; smooth muscle tissue;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; skeletal muscle tissue; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; cerebellar cortex; ; yolk sac; ; neural tube; ; superior frontal gyrus;
	More reference expression data
	n/a
Orthologs
	136895
	70821
	ENSG00000153790
	ENSMUSG00000029828
	Q8N865
	Q9D5Y0
	NM_138811; NM_001371351; NM_001371352
	NM_027564
	NP_620166; NP_001358280; NP_001358281
	NP_081840
	Wikidata
View/Edit Human	View/Edit Mouse

Chromosome Seven Open Reading Frame 31 (C7orf31) is a protein that in humans is encoded by the C7orf31 gene on chromosome seven.^[5]

Gene/Locus[edit]

In humans, the C7orf31 gene is located at the locus 7p15.3 ^[5] and stretches between position 25174316 and 25219817 (span 45502 bp).^[6] It codes for at least 4 unique human isoforms: the primary isoform (590 aa; also denoted X1, X2, and CRA_c),^[7]^[8]^[9] isoform X4 (346 aa),^[10] isoform CRA_a (580 aa),^[11] and isoform CRA_b (380 aa).^[12]

Transcript[edit]

In humans, C7orf31 codes for an mRNA strand that is 3609 base pairs long. The human mRNA is composed of a 5' untranslated region that is 561 bases and a 3' untranslated region that is 1275 bases long.^[13]

Protein[edit]

The primary protein encoded by C7orf31 in humans is 590 amino acids long with molecular weight 38334 Da.^[5] The protein is part of a functionally uncharacterized family of proteins (pfam15093) with a domain of unknown function (DUF4555).^[14]

Protein Orthology[edit]

The C7orf31 protein is well-conserved in mammals and birds, but is less conserved in more distant organisms.^[15]

C7orf31 does not have any paralogs in humans.

Expression[edit]

In humans, C7orf31 is predicted to be localized in the cytosol, nucleus, mitochondrion, and peroxisome, and it is expressed in almost all tissues.^[16] It is highly expressed especially in the testes.^[17]

Interaction[edit]

Two-hybrid studies have found interactions between the proteins encoded by A8K5H9 and C7orf31,^[18] and another study has found the protein to interact with KBTBD5.^[19]

A study in 2014 found C7orf31 to be a candidate as a centrosome-associated protein, using mass spectrometry on mammalian sperm cells’ centrioles. The protein appears in the study alongside seven other centrosome-associated protein candidates.^[20] Along with 2241 other proteins, C7orf31 also exhibited significant binding in a microarray experiment to β-amyloids, a group of proteins associated with Alzheimer's disease.^[21] Finally, in a protein-protein interaction network study,^[22] C7orf31 was found to associate with KLHL40, whose exact function is also not known.^[23]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153790 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029828 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c "NCBI Protein".
^ "UCSC Blat Results".
^ "NCBI Protein (National Center for Biotechnology Information)".
^ "NCBI Protein (National Center for Biotechnology Information)".
^ "NCBI Protein (National Center for Biotechnology Information)".
^ "NCBI Protein (National Center for Biotechnology Information)".
^ "NCBI Protein (National Center for Biotechnology Information)".
^ "NCBI Protein (National Center for Biotechnology Information)".
^ "NCBI Nucleotide (National Center for Biotechnology Information)". 11 November 2018.
^ "NCBI Conserved Domains (National Center for Biotechnology Information)".
^ "NCBI Blast (National Center for Biotechnology Information)".
^ "Genecards C7orf31".
^ "NCBI GEO (National Center for Biotechnology Information".
^ "21 binary interactions found for search term C7orf31". IntAct Molecular Interaction Database. EMBL-EBI. Retrieved 2018-08-25.
^ "STRING Database".
^ Firat-Karalar EN, Sante J, Elliott S, Stearns T (October 2014). "Proteomic analysis of mammalian sperm cells identifies new components of the centrosome". Journal of Cell Science. 127 (Pt 19): 4128–33. doi:10.1242/jcs.157008. PMC 4179487. PMID 25074808.
^ Oláh J, Vincze O, Virók D, Simon D, Bozsó Z, Tõkési N, Horváth I, Hlavanda E, Kovács J, Magyar A, Szũcs M, Orosz F, Penke B, Ovádi J (September 2011). "Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10.1074/jbc.m111.243907. PMC 3190826. PMID 21832049.
^ Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, et al. (November 2014). "A proteome-scale map of the human interactome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.
^ "NCBI Gene".

External links[edit]

Human C7orf31 genome location and C7orf31 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153790 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029828 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[NCBI_Protein_C7orf31-5] "NCBI Protein".

[6] "UCSC Blat Results".

[7] "NCBI Protein (National Center for Biotechnology Information)".

[8] "NCBI Protein (National Center for Biotechnology Information)".

[9] "NCBI Protein (National Center for Biotechnology Information)".

[10] "NCBI Protein (National Center for Biotechnology Information)".

[11] "NCBI Protein (National Center for Biotechnology Information)".

[12] "NCBI Protein (National Center for Biotechnology Information)".

[NCBI_Nucleotide_C7orf31-13] "NCBI Nucleotide (National Center for Biotechnology Information)". 11 November 2018.

[14] "NCBI Conserved Domains (National Center for Biotechnology Information)".

[NCBI_Blast-15] "NCBI Blast (National Center for Biotechnology Information)".

[16] "Genecards C7orf31".

[17] "NCBI GEO (National Center for Biotechnology Information".

[18] "21 binary interactions found for search term C7orf31". IntAct Molecular Interaction Database. EMBL-EBI. Retrieved 2018-08-25.

[19] "STRING Database".

[20] Firat-Karalar EN, Sante J, Elliott S, Stearns T (October 2014). "Proteomic analysis of mammalian sperm cells identifies new components of the centrosome". Journal of Cell Science. 127 (Pt 19): 4128–33. doi:10.1242/jcs.157008. PMC 4179487. PMID 25074808.

[21] Oláh J, Vincze O, Virók D, Simon D, Bozsó Z, Tõkési N, Horváth I, Hlavanda E, Kovács J, Magyar A, Szũcs M, Orosz F, Penke B, Ovádi J (September 2011). "Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10.1074/jbc.m111.243907. PMC 3190826. PMID 21832049.

[22] Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, et al. (November 2014). "A proteome-scale map of the human interactome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.

[23] "NCBI Gene".

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