ATOH8 (gene)

ATOH8
Identifiers
Aliases	ATOH8, HATH6, bHLHa21, atonal bHLH transcription factor 8
External IDs	MGI: 1918343 HomoloGene: 41893 GeneCards: ATOH8
Gene location (Human)
Chr.	Chromosome 2 (human)
End	85,791,383 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	72,212,561 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right lung; ; tibial nerve; ; popliteal artery; ; thoracic aorta; ; ascending aorta; ; left coronary artery; ; gastrocnemius muscle; ; upper lobe of left lung;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; aortic valve; ; ascending aorta; ; left lung; ; calvaria; ; left lobe of liver; ; right lung lobe; ; left lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein dimerization activity; DNA-binding transcription factor activity; transcription factor binding; E-box binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nuclear speck; nucleus; nucleoplasm;
Biological process	cell differentiation; positive regulation of endothelial cell differentiation; regulation of transcription, DNA-templated; SMAD protein signal transduction; transcription, DNA-templated; nervous system development; negative regulation of endothelial cell proliferation; positive regulation of endothelial cell migration; positive regulation of transcription, DNA-templated; multicellular organism development; tube formation; myoblast proliferation; formation of primary germ layer; negative regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; positive regulation of gene expression; negative regulation of gene expression; positive regulation of pri-miRNA transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	84913
	71093
	ENSG00000168874
	ENSMUSG00000037621
	Q96SQ7
	Q99NA2
	NM_032827
	NM_153778
	NP_116216
	NP_722473
	Wikidata
View/Edit Human	View/Edit Mouse

Atonal bHLH transcription factor 8 is a protein that in humans is encoded by the ATOH8 gene.^[5] It is hypothesized to play a role endochondral ossification as a regulator of chondrocyte proliferation and differentiation.^[6] In addition, it also participates in the chondrogenesis of limb bud mesenchymal progenitor cells.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168874 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037621 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Atonal bHLH transcription factor 8". Retrieved 2016-10-19.
^ Schroeder, Nadine; Wuelling, Manuela; Hoffmann, Daniel; Brand-Saberi, Beate; Vortkamp, Andrea (2019-08-26). van Wijnen, Andre (ed.). "Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones". PLOS ONE. 14 (8): e0218230. Bibcode:2019PLoSO..1418230S. doi:10.1371/journal.pone.0218230. ISSN 1932-6203. PMC 6709907. PMID 31449527.
^ Takács, Roland; Vágó, Judit; Póliska, Szilárd; Pushparaj, Peter Natesan; Ducza, László; Kovács, Patrik; Jin, Eun-Jung; Barrett-Jolley, Richard; Zákány, Róza; Matta, Csaba (2023-03-29). "The temporal transcriptomic signature of cartilage formation". Nucleic Acids Research. 51 (8): 3590–3617. doi:10.1093/nar/gkad210. ISSN 1362-4962. PMC 10164575. PMID 36987858.

Further reading[edit]

Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
Chen J, Dai F, Balakrishnan-Renuka A, Leese F, Schempp W, Schaller F, Hoffmann MM, Morosan-Puopolo G, Yusuf F, Bisschoff IJ, Chankiewitz V, Xue J, Chen J, Ying K, Brand-Saberi B (2011). "Diversification and molecular evolution of ATOH8, a gene encoding a bHLH transcription factor". PLOS ONE. 6 (8): e23005. Bibcode:2011PLoSO...623005C. doi:10.1371/journal.pone.0023005. PMC 3150394. PMID 21857980.
Güttsches AK, Balakrishnan-Renuka A, Kley RA, Tegenthoff M, Brand-Saberi B, Vorgerd M (2015). "ATOH8: a novel marker in human muscle fiber regeneration". Histochem. Cell Biol. 143 (5): 443–52. doi:10.1007/s00418-014-1299-6. PMID 25514850. S2CID 9753058.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168874 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037621 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Atonal bHLH transcription factor 8". Retrieved 2016-10-19.

[6] Schroeder, Nadine; Wuelling, Manuela; Hoffmann, Daniel; Brand-Saberi, Beate; Vortkamp, Andrea (2019-08-26). van Wijnen, Andre (ed.). "Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones". PLOS ONE. 14 (8): e0218230. Bibcode:2019PLoSO..1418230S. doi:10.1371/journal.pone.0218230. ISSN 1932-6203. PMC 6709907. PMID 31449527.

[7] Takács, Roland; Vágó, Judit; Póliska, Szilárd; Pushparaj, Peter Natesan; Ducza, László; Kovács, Patrik; Jin, Eun-Jung; Barrett-Jolley, Richard; Zákány, Róza; Matta, Csaba (2023-03-29). "The temporal transcriptomic signature of cartilage formation". Nucleic Acids Research. 51 (8): 3590–3617. doi:10.1093/nar/gkad210. ISSN 1362-4962. PMC 10164575. PMID 36987858.

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