ALS2CR8

CARF
Identifiers
Aliases	CARF, ALS2CR8, NYD-SP24, calcium responsive transcription factor
External IDs	OMIM: 607586 MGI: 2182269 HomoloGene: 11689 GeneCards: CARF
Gene location (Human)
Chr.	Chromosome 2 (human)
End	202,988,263 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	60,153,953 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; right uterine tube; ; sural nerve; ; gallbladder; ; ganglionic eminence; ; popliteal artery; ; islet of Langerhans; ; rectum; ; left lobe of thyroid gland; ; corpus callosum;
	Top expressed in
	spermatocyte; ; pineal gland; ; spermatid; ; seminiferous tubule; ; medullary collecting duct; ; superior frontal gyrus; ; olfactory tubercle; ; nucleus accumbens; ; vas deferens; ; Region I of hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	nucleolus; nucleoplasm; nucleus;
Biological process	cellular response to calcium ion; positive regulation of transcription from RNA polymerase II promoter in response to calcium ion; regulation of transcription, DNA-templated; transcription, DNA-templated; cellular response to potassium ion; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	79800
	241066
	ENSG00000138380
	ENSMUSG00000026017
	Q8N187
	Q8VHI4
NM_001104586; NM_001282910; NM_001282911; NM_001282912; NM_024744;
	NM_001322427; NM_001322428; NM_001322429; NM_001322430; NM_001352676; NM_001352677; NM_001352678; NM_001352679
	NM_001285463; NM_001285473; NM_139150
NP_001098056; NP_001269839; NP_001269840; NP_001269841; NP_001309356;
	NP_001309357; NP_001309358; NP_079020; NP_001339605; NP_001339606; NP_001339607; NP_001339608
	NP_001272392; NP_001272402; NP_631889
	Wikidata
View/Edit Human	View/Edit Mouse

Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein also known as calcium-response factor (CaRF) is a protein that in humans is encoded by the ALS2CR8 gene.^[5]^[6]

Knocking out the Carf (Als2cr8) gene in mice results in learning associated deficits. Furthermore, Carf has been shown to function as a transcription factor that regulates the expression of BDNF.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138380 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026017 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (Oct 2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298. S2CID 52828189.
^ "Entrez Gene: ALS2CR8 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8".
^ Tao X, West AE, Chen WG, Corfas G, Greenberg ME (January 2002). "A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF". Neuron. 33 (3): 383–95. doi:10.1016/S0896-6273(01)00561-X. PMID 11832226. S2CID 10874584.

External links[edit]

Human CARF genome location and CARF gene details page in the UCSC Genome Browser.

Further reading[edit]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Tao X, West AE, Chen WG, et al. (2002). "A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF". Neuron. 33 (3): 383–95. doi:10.1016/S0896-6273(01)00561-X. PMID 11832226. S2CID 10874584.
Hasan MK, Yaguchi T, Sugihara T, et al. (2002). "CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53". J. Biol. Chem. 277 (40): 37765–70. doi:10.1074/jbc.M204177200. PMID 12154087.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138380 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026017 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11586298-5] Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (Oct 2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298. S2CID 52828189.

[entrez-6] "Entrez Gene: ALS2CR8 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8".

[pmid11832226-7] Tao X, West AE, Chen WG, Corfas G, Greenberg ME (January 2002). "A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF". Neuron. 33 (3): 383–95. doi:10.1016/S0896-6273(01)00561-X. PMID 11832226. S2CID 10874584.

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