Macc1, met transcriptional regulator

MACC1
Identifiers
Aliases	MACC1, 7A5, SH3BP4L, metastasis associated in colon cancer 1, MET transcriptional regulator, MET transcriptional regulator MACC1
External IDs	OMIM: 612646; MGI: 2685113; HomoloGene: 18813; GeneCards: MACC1; OMA:MACC1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	20,217,404 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	119,433,722 bp
RNA expression pattern
	Top expressed in
	nasal epithelium; ; palpebral conjunctiva; ; mucosa of ileum; ; islet of Langerhans; ; bronchial epithelial cell; ; epithelium of nasopharynx; ; duodenum; ; oral cavity; ; secondary oocyte; ; epithelium of colon;
	Top expressed in
	epithelium of stomach; ; hair follicle; ; conjunctival fornix; ; cornea; ; skin of back; ; skin of abdomen; ; urethra; ; esophagus; ; male urethra; ; cervix;
	More reference expression data
	n/a
Gene ontology
Molecular function	growth factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	cytoplasm; mitochondrion; nucleus;
Biological process	regulation of transcription, DNA-templated; positive regulation of cell division; transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of signaling receptor activity; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	346389
	238455
	ENSG00000183742
	ENSMUSG00000041886
	Q6ZN28
	E9PXX8
	NM_182762
	NM_001163136
	NP_877439
	NP_001156608
	Wikidata
View/Edit Human	View/Edit Mouse

MACC1, MET transcriptional regulator is a protein that in humans is encoded by the MACC1 gene.^[5]

Function[edit]

MACC1 is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (HGFR) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183742 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041886 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MACC1, MET transcriptional regulator". Retrieved 2018-08-02.
^ Stein U, Walther W, Arlt F, Schwabe H, Smith J, Fichtner I, et al. (January 2009). "MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis". Nature Medicine. 15 (1): 59–67. doi:10.1038/nm.1889. PMID 19098908. S2CID 8854895.

Further reading[edit]

Kokoszyńska K, Kryński J, Rychlewski L, Wyrwicz LS (2009). "Unexpected domain composition of MACC1 links MET signaling and apoptosis". Acta Biochimica Polonica. 56 (2): 317–23. doi:10.18388/abp.2009_2464. PMID 19499089. S2CID 1822783.
Stein U, Smith J, Walther W, Arlt F (August 2009). "MACC1 controls Met: what a difference an Sp1 site makes". Cell Cycle. 8 (15): 2467–9. doi:10.4161/cc.8.15.9018. PMID 19556890.
Stein U, Dahlmann M, Walther W (January 2010). "MACC1 - more than metastasis? Facts and predictions about a novel gene". Journal of Molecular Medicine. 88 (1): 11–8. doi:10.1007/s00109-009-0537-1. PMID 19787327. S2CID 13225629.
Shirahata A, Shinmura K, Kitamura Y, Sakuraba K, Yokomizo K, Goto T, et al. (July 2010). "MACC1 as a marker for advanced colorectal carcinoma". Anticancer Research. 30 (7): 2689–92. PMID 20682999.
Shirahata A, Sakata M, Kitamura Y, Sakuraba K, Yokomizo K, Goto T, et al. (September 2010). "MACC 1 as a marker for peritoneal-disseminated gastric carcinoma". Anticancer Research. 30 (9): 3441–4. PMID 20944120.
Shimokawa H, Uramoto H, Onitsuka T, Chundong G, Hanagiri T, Oyama T, et al. (April 2011). "Overexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrence". The Journal of Thoracic and Cardiovascular Surgery. 141 (4): 895–8. doi:10.1016/j.jtcvs.2010.09.044. PMID 21093878.
Galimi F, Torti D, Sassi F, Isella C, Corà D, Gastaldi S, et al. (May 2011). "Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: response to met inhibition in patient xenografts and pathologic correlations". Clinical Cancer Research. 17 (10): 3146–56. doi:10.1158/1078-0432.CCR-10-3377. hdl:2318/110677. PMID 21447729.
Shirahata A, Fan W, Sakuraba K, Yokomizo K, Goto T, Mizukami H, et al. (March 2011). "MACC 1 as a marker for vascular invasive hepatocellular carcinoma". Anticancer Research. 31 (3): 777–80. PMID 21498695.
Chundong G, Uramoto H, Onitsuka T, Shimokawa H, Iwanami T, Nakagawa M, et al. (April 2011). "Molecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysis". Anticancer Research. 31 (4): 1141–5. PMID 21508357.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183742 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041886 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MACC1, MET transcriptional regulator". Retrieved 2018-08-02.

[pmid19098908-6] Stein U, Walther W, Arlt F, Schwabe H, Smith J, Fichtner I, et al. (January 2009). "MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis". Nature Medicine. 15 (1): 59–67. doi:10.1038/nm.1889. PMID 19098908. S2CID 8854895.

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