DescriptionTransient Dendritic Spine Growth following High-Frequency Stimulation.jpg
English: Calcium influx through NMDA receptors activates CAMKII. CAMKII then regulates several other signaling cascades that modulate the activity of the actin-binding proteins cofilin and profilin. These cascades can be divided into two primary pathways, the RhoA and Cdc42 pathways, which are mediated primarily by these members of the Rho family of GTPases. In the transient stage, the signaling cascade caused by synaptic activity results in LIMK1 phosphorylating ADF/cofilin via both the RhoA and Cdc42 pathways, which in turn inhibits the depolymerization of F-actin and increases the volume of the dendritic spine drastically while also inducing LTP.
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