File:Activation mechanisms of CAR.png
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Summary
| Description |
English: Inactivated CAR is retained in the cytosol. Upon binding of TCPOBOP, CAR gets dephosphorylated by PP2A and translocates into the nucleus. Here, it forms a complex with RXR and binds to the PB-responsive enhancer module. Another possibility to activate CAR is the indirect activation through PB. PB binds competitively to EGFR, thus inducing the dephosphorylation of RACK-1. RACK-1 then stimulates PP2A to dephosphorylate CAR, which is then translocated into the nucleus. |
| Date | |
| Source | Own work |
| Author | LisaMausi123 |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 14:14, 19 December 2014 | | 7,271 × 4,588 (739 KB) | LisaMausi123 | User created page with UploadWizard |
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