Aortic pressure

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Central aortic blood pressure (CAP or CASP) is the blood pressure at the root of aorta. Studies have shown the importance of central aortic pressure and its implications in assessing the efficacy of antihypertensive treatment with respect to cardiovascular risk factors.[1] The traditional method of measuring blood pressure in peripheral arteries, such as the brachial artery (the main artery in the upper arm) has been shown to underestimate the efficacy of medications such as amlodipine (a calcium channel blocker) and overestimate the efficacy of those like atenolol (a beta blocker). A clinical trial demonstrated that different medications for lowering blood pressure have different effects on the central aortic pressure and blood flow characteristics, despite producing similar peripheral blood pressure readings. The study also indicated that the central aortic blood pressure is a better independent predictor of negative cardiovascular (such as heart attack or stroke) and kidney (such as chronic kidney disease) outcomes than is peripheral blood pressure.[2]

Relationship to disease[edit]

Elevated central aortic blood pressure has generally been found to be a greater predictor of cardiovascular disease-related mortality and structural changes in the heart than elevated peripheral blood pressure as measured in the brachial artery (the main artery in the upper arm where blood pressure is most commonly measured).[3][1]

References[edit]

  1. ^ a b Avolio, Alberto (2008). "Central Aortic Blood Pressure and Cardiovascular Risk: A Paradigm Shift?". Hypertension. 51 (6): 1470–1471. doi:10.1161/HYPERTENSIONAHA.107.108910. ISSN 0194-911X.
  2. ^ Williams B, Lacy PS, Thom SM, et al. (March 2006). "Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study". Circulation. 113 (9): 1213–25. doi:10.1161/CIRCULATIONAHA.105.595496. PMID 16476843.
  3. ^ Kesten, Steven; Qasem, Ahmad; Avolio, Alberto (2022-10-20). "Viewpoint: The Case for Non-Invasive Central Aortic Pressure Monitoring in the Management of Hypertension". Artery Research. 28 (4): 128–139. doi:10.1007/s44200-022-00023-z. ISSN 1876-4401.

Further reading[edit]